14.12.05 18:24

GABA (gamma-aminobutyric acid)

What is GABA (gamma-aminobutyric acid) ?

This amino acid works as a neurotransmitter in the central nervous system. Mammals only have GABA in brain. Essential to brain metabolism, GABA helps human nervous system deliver a message and do appropriate brain functions. 

GABA is made in the human body through enzyme action by other amino acid named glutamic acid. GABA reduces the nerve unit cells activity, while inhibiting excessive nerve cell activity. By occupying the receptor region of brain together with niacin amide and Inositol, it stops the anxiety/ stress related messages from reaching the brain. 

GABA is mainly contained in vegetable, fruit, and crops (rice and brown rice).


GABA much contained in crops such as brown rice 


Effect of GABA

1. Helps sleeping by alleviating anxiety.

2. Sedative action, inhibiting spasm.

3. Role of promoting growth hormone and lowering blood pressure 

Growth hormone inhibits fat cells and grows muscles. GABA has been reported as increasing growth hormone(HGH) which is rapidly exhausted after one’s 40s in age. With its nontoxic and effect of the fall in blood pressure, GABA has been used as drug in many countries.

4. Due to its role in the control system of sex hormone secretion, it can be useful in prostatic hyperplasia as well.

5. Helps improve ADHD.


Related Articles

1. Neuroimaging studies in insomnia (Spiequelhalder K, Regen W, et al., Curr Psychiatry Rep. 2013 Nov;15(11):405)

: Neuroimaging of low concentration of GABA in cerebral cortex of insomnia effectives

2. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobytyric acid (GABA) in mild hypertensives. (Inoue K, Shirai T, et al., Eur J Clin Nutr 2003 Marl57(3):490-5)

: A clinical study that shows lower blood pressure in a hypertensive patient who has taken both fermented milk and GABA

3. STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. (Yang L, Cai X, et al., PLoS One, 2013 Sep 13;8(9):e74614)

: When oxygen lacks in GABA neuro transmission according to chloride concentration in cells, it can be seen that proline kinase has remarkably increased.


4. Effects of propofol on GABAergic and glutamateric transmission in isolated hippocampal single nerve-synapse preparations. (Wakita M, Kotani N, et al., Eur J Pharmacol 2013 Oct 15:718(1-3):63-73)

: Role of GABA receptor where propofol mediates depolarization between the front and the back of synapses in synapse nervous of one independent of hippocampus

5. Suppression of ATP-induced excitability in rat small-diameter trigeminal ganglion neurons by activatioon of GABAB receptor (Takeda M, Ikeda M, et al., Brain Res Bull 2013 Sep;98:115-62)

: GABA suppresses ATP-induced excitability of nerve cells.


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