Agaricus Blazei Murill
16.12.13 14:24




Agaricus Blazei Murill





What is Agaricus Blazei Murill?


Agaricus mushrooms are known as Agaricus Blazei Murill and it became widely known by the fact that Brazil natives ate Agaricus in the mid 1960s.


Agaricus mushrooms are naturally grown in the plains of Florida and South Carolina in the United State, but it has been edible by the Brazil natives in Sao Paulo piedade mountain. Most of the residents were seen to live without disease, and it was introduced to Japan and artificial cultivation was carried out for health functional food.


Among the substances having physiological activity of Agaricus mushroom, lectin is involved in hemagglutination, and (1 → 6) -β-D-glucan-protein complex and linoliec acid are known to have excellent antitumor effect.


In addition, β-glucans, proteins, and polysaccharides are compounded as a complex, and these compounds are known to have anti-cancer effect, lowering blood sugar level, lowering blood pressure and lowering cholesterol level.


Although antitumor effects are known in various mushrooms, Agaricus mushrooms contain a large amount of β-D glucan compared to other types of mushrooms.
Although β-glucans are also contained in barley and oats, β-glucans from agaricus mushrooms have structures of β-1,3 / 1,6 glucans that can be well absorbed in the body.


Currently, agaricus mushrooms are grown mainly in Japan and the United States and have been reported by Department of Agriculture to account for 95% of the total mushroom production in the United States.
On the other hand, mushrooms tend to contain heavy metals, so it is important to select the country of origin where there is little or no soil contamination, and it may be important to select products that are safe from having heavy metals.





Effects of Agaricus Mushroom


1. Anti-cancer effect.
Currently, mushrooms that are known to have anti-cancer effect are Agaricus, cloud mushroom, oyster mushroom, reishi mushroom, shiitake mushroom, and pine mushroom. Agaricus mushroom is known to have the best anti-cancer effect than other mushrooms.
In Japan, the Japanese Cancer Society announced in 1980 that it is effective not only for stomach cancer but also for other cancers such as ascites cancer, S phase colon cancer, ovarian cancer, breast cancer, lung cancer and liver cancer.
The (1 → 6) -β-D-glucan-protein complex, a polysaccharide contained in agaricus mushroom, is known to activate the immune function of normal cell tissues and prevent cancer cell proliferation and metastasis. It is reported to contain Antimutagenic and antimicrobial substances.


2. Weight and Cholesterol level control
It has been reported that the intake of protein polysaccharides (APBP, L-PBP) isolated from agaricus mushroom decreased the body weight and significantly decreased the blood LDL cholesterol level.


3. Anti-diabetic effect
Agaricus mushrooms contain a large amount of β-glucan and have been reported to exhibit anti-diabetic effects besides anti-cancer and immunosuppressive effects due to the physiological activity of having water-soluble dietary fiber characteristic.


Clinical Evidence


1. Agaricus mushroom was found to increase NK cell activity
Interleukin-12- and interferon-γ-mediated natural killer cell activation by Agaricus blazei Murill.
(Eri Yuminamochi et al., Immunology 2007 June Volume 121, Issue 2 Pages 197–206)


2. NK cell function and TNF-alpha levels were found to be significantly increased by intake of agaricus mushroom extract supplements in late stage cancer patients
Increased tumor necrosis factor alpha (TNF-alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers.
See D, Mason S, Roshan R., Immunol Invest. 31(2): 137-53. See D, Mason S, Roshan R. (2002)


3. Agaricus mushrooms have beneficial effects on cancer, infection, allergic / asthma and inflammatory diseases
The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation.
Geir Hetland et al., Advances in Pharmacological Sciences Volume 2011, Article ID 157015, 10 pages)


4. Immunological, hematological, and glycemia effects of dietary supplementation with Agaricus sylvaticus on patients' colorectal cancer.
Fortes RC, Novaes MR, Recva VL, Melo AL. (2009) Exp Biol Med (Maywood). 234 (1): 53-62.


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