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Folic Acid (B9)
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Folate What is Folate? Folic A is soluble vitamin that belongs to vitamin-B. Distributed in green plants, it was originated from a Latin word ‘folium’ which means a leaf. Today, it is normally called ‘folate’, while its supplement or folate in fortified nutrient food is known as ‘folic acid’. Folate is a nutrient helpful for making mature red blood cell. It has been used for a pregnant woman with anemia since 1930s, as the most necessary for the biosynthesis of nucleic acid and cell division. However, most types of folate forms are very unstable and easily destructive, for which folate is one of the most deficient nutrients even being contained in a variety of daily food.
ㅣBroccoli, source of supply of folate
Effect of folate 1. Normal development of embryonic neural tube The sufficient intake of folate during the early stages of pregnancy performs the important role for preventing congenital malformation and the loss of embryonic neural tube. 2. Increase reproductive ability As folate performs the role of reducing the genetic bonding of semen, it is recommended for both men and women. 3. Created new cells and red blood cells Folate is essential because it helps the synthesis of DNA and RNA and protects DNA against degeneration during new cells created. 4. Regulating normal homocysteine blood content In addition, due to bad blood circulation, it may also lead to the diseases including heart attack, stroke, cancer and Alzheimer’s disease. Related Articles 1. Folic acid supplements in pregnancy and severe language delay in children. (Roth C1, Magnus P, Schjølberg S, Stoltenberg C, Surn P, McKeague IW, Davey Smith G, Reichborn-Kjennerud T, Susser E. JAMA. 2011 Oct 12;306(14):1566-73. ) : Folic acid supplements early in pregnancy lowers the cases of severe language delay in children. 2. Effects and safety of periconceptional folate supplementation for preventing birth defects. (De-Regil LM1, Fernndez-Gaxiola AC, Dowswell T, Pea-Rosas JP. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007950.) : Folate supplementation prevents birth defects. 3. Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial. (Jaszewski R1, Misra S, Tobi M, Ullah N, Naumoff JA, Kucuk O, Levi E, Axelrod BN, Patel BB, Majumdar AP. World J Gastroenterol. 2008 Jul 28;14(28):4492-8.) : High dose of folic acid supplementation inhibits recurrence of colorectal adenomas and tumors. 4. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. (Huo Y1, Qin X, Wang J, Sun N, Zeng Q, Xu X, Liu L, Xu X, Wang X. Int J Clin Pract. 2012 Jun;66(6):544-51. ) : Folic acid supplementation is effective on stroke prevention 5. Effect of 3-year
folic acid supplementation on cognitive function in older adults in the FACIT
trial: a randomised, double blind, controlled trial. (Durga J1, van Boxtel MP,
Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P. Lancet. 2007 Jan
20;369(9557):208-16.) 6. Effects of folic
acid supplementation on hearing in older adults: a randomized, controlled
trial. (Durga J1, Verhoef P, Anteunis LJ, Schouten E, Kok FJ. Ann Intern Med.
2007 Jan 2;146(1):1-9.) 7. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. (Mangoni AA1, Sherwood RA, Swift CG, Jackson SH. J Intern Med. 2002 Dec;252(6):497-503.) : Folic acid supplementation for 4 weeks enhances endothelial function and reduces blood pressure in smokers |
